Explainable AI for
liver transplantation
I compared Cox proportional hazards, Random Survival Forest, and DeepHit to test whether molecular HLA mismatch features improve five-year liver transplant outcome prediction. I used matched cross-validation and shared preprocessing, defining all-cause graft failure as the earlier of graft failure or death.
In this cohort under the pooled endpoint, molecular HLA features did not materially improve discrimination over clinical baselines. DeepHit showed a small, variable gain. Clinical variables dominated the explainability summaries, while DR-locus physicochemical metrics showed modest signals.
CPH · Random Survival Forest · DeepHit · Model-agnostic explainability
Advisors: Dr. Robert Green · Dr. Christopher Rump